Gene information
Official symbol PDE4D
Official full name phosphodiesterase 4D
Gene type protein-coding gene
Chromosome5q11.2-q12.1
Previous symbolDPDE3
Gene familyPhosphodiesterases; MicroRNA protein coding host genes
Resources
Entrez Gene 5144
HGNC HGNC:8783
Ensembl ENSG00000113448
Vega OTTHUMG00000162218
UCSC uc003jrz.5
GO terms: 86 records
GO Description Category LogP Number of genes Detail
GO:0001885 endothelial cell development GO Biological Processes -5.33490415 11 More
GO:0001933 negative regulation of protein phosphorylation GO Biological Processes -19.8214973 59 More
GO:0002027 regulation of heart rate GO Biological Processes -9.97103962 23 More
GO:0002064 epithelial cell development GO Biological Processes -8.05661081 27 More
GO:0002764 immune response-regulating signaling pathway GO Biological Processes -3.80325753 14 More
GO:0003013 circulatory system process GO Biological Processes -65.2875605 130 More
GO:0003015 heart process GO Biological Processes -12.3962712 26 More
GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal GO Biological Processes -12.8867024 12 More
GO:0003073 regulation of systemic arterial blood pressure GO Biological Processes -22.2238525 34 More
GO:0003158 endothelium development GO Biological Processes -13.1102461 25 More
GO:0006163 purine nucleotide metabolic process GO Biological Processes -1.90037391 10 More
GO:0006753 nucleoside phosphate metabolic process GO Biological Processes -1.97459133 12 More
GO:0006937 regulation of muscle contraction GO Biological Processes -20.8046481 43 More
GO:0006942 regulation of striated muscle contraction GO Biological Processes -11.0877013 23 More
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO Biological Processes -9.16710904 33 More
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO Biological Processes -6.95524830 22 More
GO:0008015 blood circulation GO Biological Processes -65.7270163 119 More
GO:0008016 regulation of heart contraction GO Biological Processes -27.6827716 55 More
GO:0008081 phosphoric diester hydrolase activity GO Molecular Functions -7.01687804 10 More
GO:0008217 regulation of blood pressure GO Biological Processes -35.2019435 60 More
GO:0009117 nucleotide metabolic process GO Biological Processes -2.02959005 12 More
GO:0009187 cyclic nucleotide metabolic process GO Biological Processes -4.57029927 9 More
GO:0010460 positive regulation of heart rate GO Biological Processes -6.02792411 9 More
GO:0010469 regulation of signaling receptor activity GO Biological Processes -13.5880476 20 More
GO:0010563 negative regulation of phosphorus metabolic process GO Biological Processes -21.7837721 71 More
GO:0010649 regulation of cell communication by electrical coupling GO Biological Processes -4.62139945 4 More
GO:0010959 regulation of metal ion transport GO Biological Processes -23.6318171 71 More
GO:0016324 apical plasma membrane GO Cellular Components -4.50542891 15 More
GO:0016788 hydrolase activity, acting on ester bonds GO Molecular Functions -4.57583420 56 More
GO:0019439 aromatic compound catabolic process GO Biological Processes -2.08387727 10 More
GO:0019932 second-messenger-mediated signaling GO Biological Processes -19.1717114 46 More
GO:0022898 regulation of transmembrane transporter activity GO Biological Processes -11.1988499 41 More
GO:0030855 epithelial cell differentiation GO Biological Processes -14.2408795 69 More
GO:0031400 negative regulation of protein modification process GO Biological Processes -17.0986645 70 More
GO:0031690 adrenergic receptor binding GO Molecular Functions -4.18483678 6 More
GO:0032409 regulation of transporter activity GO Biological Processes -16.9480646 53 More
GO:0032412 regulation of ion transmembrane transporter activity GO Biological Processes -9.90560995 38 More
GO:0032649 regulation of interferon-gamma production GO Biological Processes -12.4733429 27 More
GO:0032663 regulation of interleukin-2 production GO Biological Processes -1.40972706 3 More
GO:0032729 positive regulation of interferon-gamma production GO Biological Processes -7.58110530 10 More
GO:0032743 positive regulation of interleukin-2 production GO Biological Processes -2.12309907 3 More
GO:0032970 regulation of actin filament-based process GO Biological Processes -7.72273150 43 More
GO:0033135 regulation of peptidyl-serine phosphorylation GO Biological Processes -8.68560410 14 More
GO:0033137 negative regulation of peptidyl-serine phosphorylation GO Biological Processes -5.46031079 9 More
GO:0034702 ion channel complex GO Cellular Components -2.54472403 10 More
GO:0034703 cation channel complex GO Cellular Components -2.87762227 9 More
GO:0034762 regulation of transmembrane transport GO Biological Processes -31.7284805 100 More
GO:0034765 regulation of ion transmembrane transport GO Biological Processes -18.4305966 71 More
GO:0042326 negative regulation of phosphorylation GO Biological Processes -20.6187298 64 More
GO:0042578 phosphoric ester hydrolase activity GO Molecular Functions -4.79997475 34 More
GO:0043269 regulation of ion transport GO Biological Processes -36.9814668 116 More
GO:0043949 regulation of cAMP-mediated signaling GO Biological Processes -2.24389415 5 More
GO:0044057 regulation of system process GO Biological Processes -61.6610386 136 More
GO:0044270 cellular nitrogen compound catabolic process GO Biological Processes -1.37456717 8 More
GO:0044325 transmembrane transporter binding GO Molecular Functions -3.08506458 7 More
GO:0045177 apical part of cell GO Cellular Components -8.17813885 46 More
GO:0045446 endothelial cell differentiation GO Biological Processes -10.3072059 20 More
GO:0045823 positive regulation of heart contraction GO Biological Processes -10.6953794 15 More
GO:0045936 negative regulation of phosphate metabolic process GO Biological Processes -21.8424865 71 More
GO:0046434 organophosphate catabolic process GO Biological Processes -3.27961839 8 More
GO:0048471 perinuclear region of cytoplasm GO Cellular Components -8.50169248 66 More
GO:0050852 T cell receptor signaling pathway GO Biological Processes -1.46333334 4 More
GO:0051279 regulation of release of sequestered calcium ion into cytosol GO Biological Processes -5.25087734 14 More
GO:0051282 regulation of sequestering of calcium ion GO Biological Processes -7.93009971 22 More
GO:0051924 regulation of calcium ion transport GO Biological Processes -18.2498286 49 More
GO:0055086 nucleobase-containing small molecule metabolic process GO Biological Processes -1.91021091 13 More
GO:0055117 regulation of cardiac muscle contraction GO Biological Processes -9.51337974 19 More
GO:0061028 establishment of endothelial barrier GO Biological Processes -4.39154198 8 More
GO:0071875 adrenergic receptor signaling pathway GO Biological Processes -8.98205881 11 More
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway GO Biological Processes -9.78130162 11 More
GO:0072521 purine-containing compound metabolic process GO Biological Processes -2.16218573 11 More
GO:0086004 regulation of cardiac muscle cell contraction GO Biological Processes -4.32093055 5 More
GO:0086103 G protein-coupled receptor signaling pathway involved in heart process GO Biological Processes -5.67855223 6 More
GO:0090257 regulation of muscle system process GO Biological Processes -33.9441291 67 More
GO:0097110 scaffold protein binding GO Molecular Functions -3.84008123 6 More
GO:0098797 plasma membrane protein complex GO Cellular Components -14.6387951 39 More
GO:1901361 organic cyclic compound catabolic process GO Biological Processes -2.75406624 12 More
GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction GO Biological Processes -3.59511628 3 More
GO:1902495 transmembrane transporter complex GO Cellular Components -2.24412383 11 More
GO:1902532 negative regulation of intracellular signal transduction GO Biological Processes -29.4927428 92 More
GO:1903115 regulation of actin filament-based movement GO Biological Processes -5.35296451 10 More
GO:1903169 regulation of calcium ion transmembrane transport GO Biological Processes -8.80532519 28 More
GO:1903522 regulation of blood circulation GO Biological Processes -44.9821911 79 More
GO:1903524 positive regulation of blood circulation GO Biological Processes -11.6803256 16 More
GO:1904062 regulation of cation transmembrane transport GO Biological Processes -18.6629834 61 More
GO:2001257 regulation of cation channel activity GO Biological Processes -11.2578208 33 More
KEGG pathways: 3 records
KEGG Description Category LogP Number of genes Detail
hsa00230 Purine metabolism KEGG Pathway -1.73406971 5 More
hsa04024 cAMP signaling pathway KEGG Pathway -7.78464854 30 More
hsa05032 Morphine addiction KEGG Pathway -3.96184640 13 More
Drug-Gene interaction
view
Related drugs: 28 records
Drug name Interaction type Source PMID View
aminophylline inhibitor ChemblInteractions view
amlexanox inhibitor ChemblInteractions view
apremilast inhibitorantagonist ChemblInteractions 2586448717352685 view
bpn-14770 allosteric modulator TTD view
cdc-801 TTD view
crisaborole inhibitor ChemblInteractions 22841723 view
denbufylline TTD view
dipyridamole inhibitor ChemblInteractions view
dyphylline inhibitor TdgClinicalTrialChemblInteractionsTEND 79256031713928417016423 view
etazolate TdgClinicalTrial view
flavoxate hydrochloride inhibitor ChemblInteractions view
gsk-356278 TTD view
ht-0712 TTD view
lirimilast TTD view
mk-0873 TTD view
oglemilast TTD 18660832 view
oxtriphylline inhibitor ChemblInteractions view
papaverine TTD view
pentoxifylline inhibitor ChemblInteractions view
piclamilast TTD 1059223515765929 view
quetiapine PharmGKB view
resveratrol TdgClinicalTrial view
revamilast TTD view
roflumilast inhibitor ChemblInteractions 1772634310592235 view
rolipram inhibitor TTD 105922351713928417016423 view
theophylline inhibitor ChemblInteractions view
theophylline sodium glycinate inhibitor ChemblInteractions view
tofimilast TTD view
Related studies: 2 records
Molecular factor Omics type Application Objective MI type Reference
NC_000005.10:g.[60174072G>A;60365629A>G;60206693A>G;60298071A>G;60304214G>C;60354709A>G] genomics myocardial infarction[diagnosis] myocardial infarction Rodriguez-Perez JM et al. Excli j. 2018
NG_027957.2:g.322637T>C genomics myocardial infarction[diagnosis] myocardial infarction Pleskach HV et al. Lik Sprava. 2012
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